A History of the Mad Scientist, Part One - io9
"The mad scientist is one of the standard archetypes of modern popular culture. Widespread in the pulps of the 1920s and 1930s, its modern inception dates back to Mary Shelley's Frankenstein (1818)..."
http://io9.com/5805477/alchemists-astronomers-and-wild-men-a-history-of-the-mad-scientist-part-one